The San Francisco 49ers will make the road trip in a week fourteen NFC west divisional NFL pro football game against rivals the Arizona Cardinals on Sunday afternoon.
This NFL game will begin from Arizona at 4PM Eastern Time with national television coverage provided by FOX.
The point spread came in with the road team San Francisco 49ers favored by –3 1/2 points with an over under of 40 ½ points.
The early money from the NFL betting public has come in on the side of the road club as the San Francisco 49ers have been bet up to a -4 point favorite.
The total has moved towards the under as the game is now lined at 39 ½ points.
Those betting the favored San Francisco 49ers on the money line will lay –200 odds with the underdog Arizona Cardinals returning +170 odds to win straight up with no need for points on their side.

These two NFC west rivals meet on Sunday for the second and final time this regular season.
They first met in 2010 four Sunday’s ago and it was the San Francisco 49ers with the 23-7 home win against the Arizona Cardinals as a -10 point betting favorite.
The total came in at under the closing line of 40 ½ points.
San Francisco stormed out to the 23-0 lead after three quarters and allowed a Cardinals touchdown midway through the fourth quarter.
The 49ers ran effectively in the win with 164 yards on 49 carries.
Quarterback Alex Smith had two touchdowns and a pick to go with his 267 yards passing in the win.
Michael Crabtree came in big for San Francisco with 120 receiving yards on 7 catches.
John Skelton had a miserable day throwing three interceptions and completing just 6 of 19 passes.
San Francisco heads to the desert to face Arizona with a mark of 10-2 on the season. The team has clinched the NFC west division. The 49ers are 4-1 on the road.
San Francisco puts up 24 points and 315 yards per game with 130 rushing yards for 4.2 yards a carry.
On defense the 49ers allow 13 points and 303 yards per game. Teams rush for 71 yards against them for 4.6 yards per rush against average.
The 49ers are coming off the 26-0 home win against the St Louis Rams last week as a -14 point betting favorite.
The over under came in at under the closing line of 38 ½ points.
San Francisco piled up 389 offensive yards with 144 coming on the ground on 34 carries.
The team allowed four sacks and scored no red zone touchdowns in their four tries inside the twenty.
The club had no turnovers and took two from the Rams.
Quarterback Alex Smith completed 17 of 23 passes for 274 yards with two touchdowns.
Frank Gore ran for 73 yards on 21 carries.
Kyle Williams had a 25 yard run from scrimmage.
Michael Crabtree had four receptions for 96 yards and a receiving touchdown.
Kyle Williams caught two passes for 66 yards and a touchdown.
Ted Ginn Jr. had four grabs for 56 yards.
Vernon Davis chipped in with five catches for 32 yards.
The 49ers allowed St Louis just 157 yards of offense with 31 rushing yards on 23 carries.
San Francisco had four sacks and allowed no red zone appearances by the Rams.

The Arizona Cardinals will host San Francisco with a record of 5-7 on the year. The team is 3-2 at home.
Arizona averages 19 points and 316 yards per game with 108 yards rushing for 4.5 yards a carry.
On defense the Cardinals give up 22 points and 370 yards per game. Teams rush for 119 yards against them for 4 yards per rush against average.
Arizona may have waited too long to get good as the team has won four of their past five games.
They are coming off the 19-13 home overtime win a week ago to the Dallas Cowboys as a +4 point underdog.
The over under landed under the closing line of 46 ½ points.
Arizona gained 327 offensive yards with 103 rushing yards on 25 carries.
The team allowed five sacks and scored one touchdown in two red zone appearances.
They had no turnovers and took none from Dallas.
Quarterback Kevin Kolb completed 16 of 25 passes for 247 yards with a touchdown. Kolb had three rushes for 20 yards.
Beanie Wells ran for 67 yards and a touchdown on 20 carries.
LaRod Stephens Howlins had two rushes for 16 yards. Out of the backfield Howling had a 52 yard touchdown reception in overtime for the win.
Andre Roberts led Arizona with six receptions for 111 yards.
Larry Fitzgerald caught four passes for 55 yards.
Robert Housler had two grabs for 23 yards.
The Cardinals gave up 336 yards of offense to the Cowboys with 75 rushing yards on 20 runs from scrimmage.
Arizona had five sacks and gave up one Dallas touchdown in their two trips inside the red zone.
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NFL Trend: San Francisco 49ers are 6-1 to the under in their past seven games.
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